KMID : 1134120220250060485
|
|
Journal of Breast Cancer 2022 Volume.25 No. 6 p.485 ~ p.499
|
|
Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Early Standardized Uptake Value Reduction in Patients With Breast Cancer Receiving Neoadjuvant Chemotherapy
|
|
Bae Soong-June
Ahn Sung-Gwe Ji Jung-Hwan Kim Doo-Reh Park So-Eun Cha Chi-Hwan Jeong Joon
|
|
Abstract
|
|
|
Purpose : We investigated the treatment response and prognosis using the neutrophil-to-lymphocyte ratio (NLR) and standardized uptake value (SUV) of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in neoadjuvant settings.
Methods : Baseline NLR and maximum SUV (SUVmax) were retrospectively analyzed in 273 females with breast cancer who received neoadjuvant chemotherapy followed by surgery. Of these, 101 patients underwent 18F-FDG PET after 3?4 neoadjuvant chemotherapy cycles, which allowed the measurement of ¥ÄSUVmax, an early reduction in SUVmax. NLR and early SUVmax reduction (¥ÄSUVmax) were classified as low and high, respectively, relative to the median values.
Results : The mean NLR was lower, and the mean ¥ÄSUVmax was higher in patients with pathologic complete response (pCR) than in those with residual tumors. The ¥ÄSUVmax was an independent variable associated with pCR. Furthermore, the high NLR group had poor recurrence-free survival (RFS) and overall survival. Among patients with ¥ÄSUVmax data, high NLR (adjusted hazard ratio, 2.82; 95% confidence intervals [CI], 1.26?6.28; P = 0.016) and low ¥ÄSUVmax (adjusted hazard ratio, 2.39; 95% CI, 1.07?5.34; P = 0.037) were independent prognostic factors for poor RFS. The categorization of the patients into four groups according to the combination of NLR and ¥ÄSUVmax showed that patients with high NLR and low ¥ÄSUVmax had significantly poorer RFS.
Conclusion : Baseline NLR and ¥ÄSUVmax were significantly associated with the prognosis of patients with breast cancer who received neoadjuvant chemotherapy. These results suggest that metabolic non-responders with defective immune systems have worse survival outcomes.
|
|
KEYWORD
|
|
Breast Neoplasms, Lymphocytes, Neoadjuvant Therapy, Neutrophils, Positron Emission Tomography Computed Tomography
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|